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. 2016 Oct 30;94:59–71. doi: 10.1016/j.ejps.2016.03.018

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© 2016 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — Comparison of observed and predicted F_reab using the mechanistic tubular reabsorption model and P_app data obtained in Caco-2 cells. Panel A: Predicted relationship between F_reab and P_app is shown by the solid black line, whereas observed data are shown by symbols; Panel B: Predicted/observed F_reab are plotted as symbols, whereas solid and dashed black lines indicate Predicted/observed = 1 and 3-fold error, respectively. Symbols indicate neutral (), basic (), acidic (), zwitterion () and amphoteric () drugs. Drugs with negative values for observed F_reab are plotted as F_reab = 0 in Panel A, or predicted/observed F_reab = 100 in Panel B, as described in the Materials and methods.

Comparison of observed and predicted F_reab using the mechanistic tubular reabsorption model and P_app data obtained in Caco-2 cells. Panel A: Predicted relationship between F_reab and P_app is shown by the solid black line, whereas observed data are shown by symbols; Panel B: Predicted/observed F_reab are plotted as symbols, whereas solid and dashed black lines indicate Predicted/observed = 1 and 3-fold error, respectively. Symbols indicate neutral (), basic (), acidic (), zwitterion () and amphoteric () drugs. Drugs with negative values for observed F_reab are plotted as F_reab = 0 in Panel A, or predicted/observed F_reab = 100 in Panel B, as described in the Materials and methods.