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Best-fit curve and 90% confidence interval of the Hill equation to the Papp and Freab′ data for 45 drugs (solid and dashed lines respectively). Symbols indicate neutral (
), basic (
), acidic (
), zwitterion (
) and amphoteric (
) drugs. Drugs with negative values for observed Freab′ are plotted as Freab′ = 0, as described in the text.
