Table 1.

Physiological parameter values used for tubular compartments in the minimal physiologically-based reabsorption model.

	TSAi (m2)	TFRi (mL/min)a
PT	6.1	81.6 (120–43.2)
LoH	0.16b	33.6 (43.2–24.0)
DT	0.21b	17.8 (24.0–11.6)
CD	0.045b, c	6.3 (11.6–1.0)

^aValues represent midpoint flow rates, ranges in parentheses represent flows at beginning and end of tubule regions.

^bTSA_LoH, TSA_DT and TSA_CD calculated accounting for microvilli.

^cTSA_CD includes an exponential function for calculating surface area of inner medulla CD. Details are listed in the Supplementary Methods.