Figure 2. Activation of ATM following TCR restimulation.
(A) Phosphorylation of p53 and ATM and (B) Annexin V staining in CD8+ T cells 120 min after TCR restimulation. Data shown are representative results (left panels) and averages ± SEM from 3 donors (right panels). Caffeine (10mM) or KU-55933 (100uM) was added one hour before restimulation of the TCR with anti-CD3. *p<0.05, ns=not significant.