Figure 1.

Bregs play their roles in immune response through IL‐10, TGF‐β, and/or IL‐35. a: IL‐10‐producing Bregs appear to suppress the differentiation of Th1/Th17 cells and enhance Th2 polarization. IL‐10‐producing Bregs also suppress macrophage and dendritic cells activation. b: TGF‐β‐producing Bregs appear to suppress Th1 activation and promote Tregs expansion. c: i35‐Bregs appear to suppress Th1/ Th17 activation and promote Tregs expansion. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]