. 2016 Apr 26;94(8):693–701. doi: 10.1002/jnr.23749

Table 1.

Phenotypic Characterization of Regulatory B Cells in Mice and Humans

Species	Phenotypes/markers	Relevance to disorders/models^a	References
Mice	CD19⁺CD5⁺CD1d^hi	CHS, EAE	Matsushita et al., 2008; Yanaba et al., 2008
	CD1d^hiCD21^hiCD23⁻CD24^hiIgM^hiIgD^lo	IBD	Wei et al., 2005
	TIM‐1⁺B	EAE	Ding et al., 2011
	CD1d^hiCD21^hiCD23⁺CD24^hilgM^hiIgD⁺	Experimental arthritis	Evans et al., 2007
	CD19⁺CD25⁺B220⁺	Breast cancer	Olkhanud et al., 2011
Human	CD19⁺CD5⁺CD1d^hi	NMO, CHB, CHC	Wang et al., 2014a; Yang et al., 2015
	CD19⁺CD5⁺Foxp3⁺	Normal subjects	Noh et al., 2010
	CD19⁺CD24^hiCD27⁺	cGVHD, RA, SS, SLE	Iwata et al., 2011; Daien et al., 2014; de Masson et al., 2015
	CD19⁺CD25⁺	MS	de Andres et al., 2014
	CD19⁺CD38⁺CD1d⁺IgM⁺CD147⁺	Solid tumors	Lindner et al., 2013
	CD5⁺CD24^hiCD38^hi	AAV	Aybar et al., 2015
	CD19⁺CD24^hiCD38^hi	MS, NMO, SLE, RA, SS, pemphigus, ITP, AAV	Blair et al., 2010; Furuzawa‐Carballeda et al., 2013; Wilde et al., 2013; Daien et al., 2014; Hua et al., 2014; Zhu et al., 2015

CHS, contact hypersensitivity; IBD, inflammatory bowel disease; CHB, chronic hepatitis B; CHC, chronic hepatitis C; cGVHD, chronic graft versus host disease; RA, rheumatoid arthritis; SS, primary Sjogren's syndrome; AAV, ANCA‐associated vasculitis; ITP, immune thrombocytopenia.