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. 2016 Apr 19;55(23):6767–6770. doi: 10.1002/anie.201602852

Scheme 1.

Scheme 1

Alternative approaches for the conversion of aldehydes 1 into α‐fluoro β‐hydroxy carboxylic acids 6. a) Reaction with an enolate of an ester of fluoroacetic acid 2, followed by hydrolysis. b) Aldolase‐catalysed reaction with fluoropyruvic acid (4), followed by decarboxylation.