Table 5.

Multivariable Model

Factor	Parameter Estimate	Standard Error	P	Hazard Ratio	95% HR Confidence Limits
Presence of extramedullary disease	−0.038	0.090	.671	0.963	0.807 to 1.148
No. of extramedullary sites	0.277	0.187	.138	1.320	0.915 to 1.903
Year registered to study	−0.022	0.003	.000	0.978	0.973 to 0.983
Age	0.023	0.001	.000	1.024	1.021 to 1.026
Log WBC	0.068	0.015	.000	1.070	1.040 to 1.102
Log platelets	−0.059	0.023	.010	0.943	0.902 to 0.986
Hemoglobin	−0.022	0.010	.024	0.978	0.960 to 0.997
PS 1*	0.128	0.045	.005	1.136	1.039 to 1.242
PS 2-4*	0.193	0.062	.002	1.213	1.075 to 1.368
Male	0.067	0.040	.094	1.070	0.988 to 1.158
Extramedullary site: gingiva	−0.118	0.211	.576	0.888	0.587 to 1.345
Extramedullary site: nodes	−0.237	0.199	.235	0.789	0.534 to 1.166
Extramedullary site: spleen	−0.157	0.201	.436	0.855	0.576 to 1.268
Extramedullary site: liver	−0.204	0.203	.314	0.815	0.548 to 1.213
CNS involvement	−0.331	0.286	.247	0.718	0.410 to 1.257
Extramedullary site: skin	−0.098	0.213	.648	0.907	0.597 to 1.378
Extramedullary site: lung	−0.087	0.303	.774	0.917	0.507 to 1.659
Extramedullary site: bone	−0.277	0.448	.537	0.758	0.315 to 1.826
Myeloid sarcoma	−0.433	0.426	.309	0.648	0.281 to 1.494
FAB intermediate risk*	0.024	0.049	.619	1.025	0.931 to 1.128
FAB high risk*	0.185	0.089	.038	1.203	1.010 to 1.433
FAB other*	0.087	0.069	.207	1.091	0.953 to 1.248
Achieved CR to induction	−1.132	0.042	.000	0.322	0.297 to 0.350

Abbreviations: CR, complete remission; FAB, French-American-British; PS, performance status.

^*Reference categories are PS 0, favorable risk cytogenetics.