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The Simcyp liver cirrhosis population PBPK module, which incorporates changes in physiology including cytochrome P450 expression/activity owing to cirrhosis but not changes in transporter expression, was used to predict repaglinide disposition in liver cirrhosis patients (A). Incorporation in the model of changes in OATP1B1 expression owing to cirrhosis improved the prediction of repaglinide disposition in liver cirrhosis patients (B). The observed data are from Hatorp et al. (2000).
