TABLE 1.
Paired estimated PK parameters for BUP during mid-pregnancy compared with late pregnancy; and late pregnancy compared with postpartum
Data presented as mean ± S.D. Mid-pregnancy, 22–26 weeks of gestation; late pregnancy, 34–38 weeks of gestation.
| Parameter | Mid-pregnancy (n = 8) | Late Pregnancy (n = 8) | Late Pregnancy (n = 12) | Postpartum (n = 12) | |
|---|---|---|---|---|---|
| BUP | AUCss BUP (ng × h/ml) | 640 ± 263 | 554 ± 214 | 654 ± 301 | 775 ± 291 |
| CL/Fss (L/h) | 359 ± 389 | 321 ± 152 | 259 ± 117 | 208 ± 93 | |
| CL/Fss (L/h/kg) | 4.37 ± 4.41 | 3.74 ± 2.29 | 3.10 ± 1.27 | 2.85 ± 1.79 | |
| OHBUP | AUCss OHBUP (ng × h/ml) | 9008 ± 3191 | 10,092 ± 3865 | 9499 ± 3893 | 9857 ± 6032 |
| OHBUP/BUP M.R. | 22.5 ± 28.1 | 21.3 ± 10.7 | 17.7 ± 10.7 | 14.1 ± 8.60 | |
| TB | AUCss TB (ng × h/ml) | 4843 ± 3196 | 3911 ± 2896 | 4105 ± 2564 | 4164 ± 3232 |
| TB/BUP M.R. | 7.91 ± 4.01 | 7.58 ± 4.63 | 6.79 ± 3.60 | 5.21 ± 3.10 | |
| EB | AUCss EB (ng × h/ml) | 759 ± 447 * | 541 ± 370 | 621 ± 387 | 871 ± 586 |
| EB/BUP M.R. | 1.33 ± 0.65 * | 1.06 ± 0.57 | 1.01 ± 0.51 | 1.10 ± 0.59 |
M.R., metabolic ratio, defined as the ratio of AUCs, corrected for mol. wt.
*
P < .05.