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. 2016 Nov;359(2):273–279. doi: 10.1124/jpet.116.235945

Fig. 3.

Fig. 3.

Priming effect of Orx-A/Hcrt-1. (A) Time course of cocaine self-administration over the 21 days of training. Tukey post hoc tests *P < 0.05; **P < 0.01; ***P < 0.001 vs. respective previous day (data shown depict the mean ± S.E.M.; n = 38). Intra-pPVT administration of Orx-A/Hcrt-1 induces cocaine-seeking behavior. *P < 0.05; **P < 0.01; vs. 0 μg (saline). ∆, % increase in responding): *P < 0.05; **P < 0.01 vs. 0 μg (saline). Asterisks (*, **) are referring to both the responses and the % increase. EXT, extinction; SHAM, sham injection (data shown depict the mean ± S.E.M; n = 38 for EXT and SHAM; n = 7–9 for Orx-A/Hcrt-1 doses).