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. 2016 Nov;359(2):273–279. doi: 10.1124/jpet.116.235945

Fig. 5.

Fig. 5.

Effect of TCSOX229 Orx-A/Hcrt-1’s priming effect (A) Cocaine intake over the self-administration days. Tukey post hoc tests: *P < 0.05; **P < 0.01 vs. respective previous day (data shown depict the mean ± S.E.M; n = 34). (B) Reversal of Orx-A/Hcrt-1 (0.5 µg) priming effect by TCSOX229. *P < 0.05; **P < 0.01 vs. VEH (saline); #P < 0.05, vs. 0 μg (Orx-A/Hcrt-1 alone). ∆: % decrease responding: *P < 0.05, vs. VEH (saline); #P < 0.05, vs. 0 μg (Orx-A/Hcrt-1 alone). Symbols (*, #) refers to both the responses and the % decrease. EXT, extinction; SHAM, sham injection; VEH, vehicle (data shown depict the mean ± S.E.M; n = 34 for EXT and SHAM; n = 9 for VEH; n = 6 to 7 for TCSOX229 doses).