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. 2016 Oct 21;11(10):e0164763. doi: 10.1371/journal.pone.0164763

Fig 2. Effects of dexmedetomidine on isoflurane-induced apoptosis in hippocampus.

Fig 2

Representative photomicrographs of the hippocampal CA1 region from senile mice at 19 d after treatment with nothing (control) or with isoflurane (ISO) following pretreatment with nothing or with dexmedetomidine (DEX). Some animals were pretreated with atipamezole (Atip), AG490 or WP1066 prior to DEX. Apoptosis was assessed using terminal deoxynucleotidyl transferase dUTP nick end (TUNEL) staining (A), and TUNEL-positive cells were counted (B). Scale bar, 50 μm. Data are represented as mean ± SD (n = 8). *P< 0.05 vs. control group; #P< 0.05 vs. ISO group; &P< 0.05 vs. DEX group.