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. Author manuscript; available in PMC: 2016 Oct 21.
Published in final edited form as: Hum Mutat. 2008 May;29(5):640–647. doi: 10.1002/humu.20692

FIGURE 1.

FIGURE 1

Genomic DNA sequence analysis of the PLN promoter region. A: Partial nucleotide sequences of the PLN promoter region in normal subjects and DCM patients heterozygous for the AF177763.1:g.203A>C (at −36bp from transcriptional start site: −36A>C) substitution. B: Sequence comparison of the proximal mammalian PLN promoter sequences was performed by the FASTA program (http://fasta.bioch.virginia.edu/fasta_www2/fasta_list2.shtml) (GenBank reference sequence numbers AF177763.1, AF037348.1, L03381.1, and M63600.1). The numbers correspond to human nucleotides upstream of exon 1 (transcription start site, underlined). The position of the A>C transition (boxed) is indicated. Gaps are shown by dash. Polymorphism numbering is based on using the GenBank accession numberAF177763.1for human PLN sequence corresponding to proximal promoter and exon1and the transcription start site as a reference. [Color figure can be viewed in the online issue, which is available at http://www.interscience.wiley.com.]