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. 2016 Oct 21;11(10):e0165093. doi: 10.1371/journal.pone.0165093

Fig 9. PI3K, caspase-3 and Bcl-2 mRNA levels detected using RT-PCR analysis in focal cerebral ischemia/reperfusion rats.

Fig 9

PI3K and Bcl-2 mRNA expression in the ischemic cortexes of the cerebral ischemia/reperfusion rats was higher in the rLj-RGD3 groups than in the VT group. The level of caspase-3 mRNA was significantly lower in the rLj-RGD3 groups. rLj-RGD3 up-regulates PI3K and Bcl-2 mRNA levels and down-regulates caspase-3 mRNA expression. We therefore conclude that rLj-RGD3 is able to activate the PI3K/AKT anti-apoptosis pathway. The drug Eptifibatide resulted in expression levels that were less significantly higher than those in the rLj-RGD3 100.0 μg·kg-1 group (p <0.05). ## p<0.01 vs. the sham group, **p <0.01 vs. the VT group. The data are shown as the means ± SD. For RT-PCR, one-way ANOVA was used to compare DNA bands between groups after ischemia.