Table 6.
Suggestive Sex-stratified Associations
| Model | SNP | B37 Region | SNPs in Region | Genes in Region | N | CAF | β (SE) BMI Adjusted | β (SE) BMI Unadjusted | P Value | Direction |
|---|---|---|---|---|---|---|---|---|---|---|
| AHI females | rs199803244 A | 12p11:27,645,082–27,659,326 | 3 | SMCO2 | 6,691 | 0.945/NA/NA | 0.182 (0.035) | 0.187 (0.037) | 1.64 × 10−7 (4.98 × 10−7) | +?? |
| rs11897825 A | 2p24:21,694,451 | 1 | AC011752.1, AC067959.1 | 6,691 | 0.606/NA/NA | −0.085 (0.017) | −0.090 (0.018) | 4.34 × 10−7 (5.26 × 10−7) | −?? | |
| AHI males | rs11588454 T | 1q31:191,618,878–191,808,947 | 14 | 5,062 | 0.750/0.710/0.701 | −0.114 (0.021) | −0.124 (0.023) | 6.97 × 10−8 (8.04 × 10−8) | −+− | |
| rs140743827 A | 1q23:164,985,756 | 1 | 4,626 | 0.018/NA/NA | 0.392 (0.076) | 0.428 (0.083) | 2.26 × 10−7 (2.27 × 10−7) | +?? | ||
| rs4796285 A | 17q12:35,181,996 | 1 | 5,062 | 0.581/0.556/0.593 | −0.096 (0.019) | −0.092 (0.020) | 3.09 × 10−7 (7.15 × 10−6) | −+− | ||
| rs111942351 A | 5q31:143,073,550 | 1 | CTB-57H20.1 | 4,842 | 0.981/0.984/NA | 0.363 (0.071) | 0.338 (0.078) | 3.75 × 10−7 (1.34 × 10−5) | ++? | |
| SpO2 males | rs11074782 T | 16p12:26,505,011 | 1 | 5,076 | 0.230/0.205/0.263 | −0.112 (0.022) | −0.113 (0.024) | 2.95 × 10−7 (1.55 × 10−6) | −+− | |
| Event duration females | rs78897171 A | 20q13:60,443,251 | 1 | CDH4 | 5,589 | 0.023/NA/NA | 0.106 (0.020) | 0.108 (0.020) | 1.63 × 10−7 (1.12 × 10−7) | +? |
| rs35329661 T | 11q13:74,974,990 | 1 | ARRB1, CTD-2562J17.7, CTD-2562J17.9 | 5,589 | 0.013/NA/NA | 0.132 (0.026) | 0.134 (0.026) | 2.80 × 10−7 (2.06 × 10−7) | +? | |
| Event duration males | rs148024591 T | 15q26:93,906,988–93,927,482 | 10 | RP11-266O8.1 | 4,414 | 0.017/0.015/NA | 0.119 (0.021) | 0.117 (0.022) | 2.81 × 10−8 (6.72 × 10−8) | ++ |
| rs4849682 T | 2q14:118,911,223–118,942,883 | 2 | AC093901.1 | 4,414 | 0.290/0.320/NA | −0.032 (0.006) | −0.030 (0.006) | 1.07 × 10−7 (4.56 × 10−7) | −− | |
| rs11610782 A | 12q24:126,196,289–126,256,105 | 2 | 4,204 | 0.024/NA/NA | 0.109 (0.021) | 0.108 (0.021) | 3.01 × 10−7 (3.69 × 10−7) | +? |
Definition of abbreviations: AHI = apnea–hypopnea index; BMI = body mass index; CAF = coded allele frequency; NA = not available; SNP = single-nucleotide polymorphism; SpO2 = average percentage of oxyhemoglobin saturation.
P values in parentheses were obtained from equivalent BMI-unadjusted model results. CAF and direction columns are ordered from left to right as Hispanic Community Health Study/Study of Latinos, Multi-Ethnic Study of Atherosclerosis, and Starr County. Event duration was not collected in Starr County.