Table 2.

Therapeutic agents for Paget’s disease of bone and major treatment regimens

Compound	Dose
Calcitonin	50–100 U/day subcutaneously or 3 times a week for 6–18 months
Etidronate	400 mg/day for 3 months
Tiludronate	400 mg/day for 3 months
Clodronate	400–1600 mg/day orally for 3–6 months or 300 mg/day intravenously for 5 days
Pamidronate	30–60 mg/day intravenously for 3 days
Alendronate	40 mg/day for 6 months
Risedronate	30 mg/day for 2 months
Zoledronate	5 mg intravenously by a single infusion
Neridronate	200 mg intravenously by a single infusion on 2 consecutive days