The subfigures (
a) and (
c) were generated using the seed alignment sequences from Pfam family
TPR_1 (558 sequences. Sequence Q29585_PIG/28–61 was removed as it contains unknown residue X). The largest mutual information value is observed between position 7 and 23. The subfigures (
b) and (
d) were generated using the multiple alignment of representative proteomes rp75 sequences from Pfam family
TPR_1 (9338 sequences). The largest non-local mutual information value was observed between position 24 and 47, corresponding to position 7 and 23 using TPR repeat numbering. Alignments were taken from Pfam 27.0. Subfigures (
a) and (
b) were generated using MatrixPlot. Subfigures (
c) and (
d) were generated using DCA Workbench (
http://dca.rice.edu/portal/dca/workbench).