Table 2.
Diffusion Tensor Imaging Studies of Typical Development of FA within the Cingulum and Anterior Thalamic Radiations
| N | Age | FA Changea | T | b-value | Directions | Cingulum ROI | ATR ROI | |
|---|---|---|---|---|---|---|---|---|
| Longitudinal Region-of-Interest Studies | ||||||||
| Brouwer 2012 | 126 | 9–12 | ↑ | 1.5 | 1000 | 32 | Yes | - |
| Lebel 2011 | 103 | 5–32 | ↑ | 1.5 | 1000 | 6 | Yes | - |
| Simmonds 2014 | 128 | 8–29 | ↑ | 3 | 800 | 6 | Yes | Yes |
|
| ||||||||
| Cross-sectional Region-of-Interest Studies | ||||||||
| Bonekamp 2007 | 40 | 5–19 | ↑ | 1.5 | 1000 | 15 | Yes | Yes |
| Cancelliere 2013 | 202 | 0–18 | - | 1.5 | 1000 | 15 | - | Yes |
| Clayden 2012 | 53 | 8–16 | ↑ | 1.5 | 1000 | 20 | Yes | Yes |
| Faria 2010 | 35 | 2–40 | ↑ | 1.5 | 700 | 32 | Yes | Yes |
| Grieve 2011 | 213 | 7–86 | ↑ | 1.5 | 1250 | 12 | Yes | - |
| Imperati 2011 | 144 | 7–48 | ↑ | 3 | 1000 | 64 | Yes | Yes |
| Kochunov 2012 | 831 | 11–90 | ↑ | 3 | 700 | 55 | Yes | Yes |
| Lebel 2008 | 202 | 5–30 | ↑ | 1.5 | 1000 | 6 | Yes | Yes |
| Lebel 2012 | 403 | 5–83 | ↑ | 1.5 | 1000 | 6 | Yes | Yes |
| Lobel 2009 | 72 | 0–19 | ↑ | 1.5 | 1000 | 6 | - | Yes |
| Moon 2011 | 87 | 4–17 | ↑ | 3 | 1000 | 6 | - | Yes |
| Peters 2014 | 296 | 8–68 | ↑↓b | 3 | 1000 | 31 | Yes | Yes |
| Qiu 2008 | 75 | 6–26 | ↑ | 3 | 1000 | 6 | - | Yes |
| Rollins 2010 | 32 | 6–18 | ↑ | 3 | 700 | 30 | Yes | Yes |
| Sala 2012 | 84 | 13–70 | ↓ | 1.5 | 900 | 12 | Yes | - |
| Snook 2005 | 60 | 8–27 | ↑ | 1.5 | 1000 | 6 | - | Yes |
| Stadlbauer 2008 | 38 | 18–88 | - | 3 | 1000 | 6 | Yes | - |
| Supekar 2010 | 33 | 7–22 | ↑ | 3 | 850 | 23 | Yes | - |
| Taki 2013 | 290 | 5–18 | ↑ | 3 | 1000 | 32 | Yes | - |
| Tamnes 2010 | 168 | 8–30 | ↑ | 1.5 | 700 | 30 | Yes | - |
| Trivedi 2009 | 51 | 0–21 | ↑ | 1.5 | 700 & 1000 | 10 | Yes | - |
| Verhoeven 2010 | 78 | 0–24 | ↑ | 3 | 800 | 45 | Yes | Yes |
| Westlye 2010 | 430 | 8–85 | ↑ | 1.5 | 700 | 30 | Yes | Yes |
| Yu 2014 | 65 | 0–25 | ↑ | 3 | 1000 | 30 | Yes | - |
|
| ||||||||
| Longitudinal Voxelwise Studies | Cingulum Sig | ATR Sig | ||||||
| Bava 2010 | 22 | 16–21 | ↑ | 3 | 2000 | 15 | - | Yes |
| Giorgio 2010 | 24 | 13–18 | ↑ | 1.5 | 1000 | 60 | Yes | Yes |
| Wang 2012 | 16 | 13–17 | ↑ | 1.5 | 1000 | 32 | Yes | Yes |
|
| ||||||||
| Cross-sectional Voxelwise Studies | ||||||||
| Ashtari 2007 | 24 | 10–20 | ↑ | 1.5 | 1000 | 25 | Yes | - |
| Barnea-Goralay 2005 | 34 | 6–19 | - | 1.5 | 900 | 6 | - | Yes |
| Brauer 2011 | 20 | 5–32 | ↑ | 1.5 | 1000 | 60 | Yes | Yes |
| Faria 2010 | Listed above | - | - | |||||
| Giorgio 2008 | 42 | 13.5–42 | - | 1.5 | 1000 | 60 | - | - |
| Peters 2012 | 78 | 8–21 | ↑ | 1.5 | 1000 | 31 | Yes | Yes |
| Qiu 2008 | Listed above | Yes | Yes | |||||
| Qiu 2010 | 96 | 11–25 | ↑ | 3 | 1000 | 12 | Yes | Yes |
| Schmithorst 2002 | 33 | 5 – 18 | - | 3 | 814/994 | 6 | - | Yes |
| Stevens 2009 | 50 | 11–37 | ↑ | 3 | 1000 | 12 | - | - |
| Taki 2013 | Listed above | - | - | |||||
Note. Studies included in the meta-analysis are bolded. Characteristics of studies reporting both ROI and voxelwise analyses are listed only once.
a
The direction of FA change refers to the adolescent period, not lifespan change.
b
Peters et al. (2014) found increased FA of the cingulum, and decreased FA for the ATR.