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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Neurosci Biobehav Rev. 2016 May 24;70:4–12. doi: 10.1016/j.neubiorev.2016.05.013

Figure 2. Periadolescent changes in GABAergic function are associated with shifts in dominance of GABAergic populations in the PFC.

Figure 2

(A) Early adolescent rats exhibit lower levels of PV expression in the PFC when compared to adults, a developmental hallmark that is associated with diminished glutamatergic transmission onto PV-positive, fast-spiking interneurons (PV/FSI). On the other hand, the expression of CR in the PFC is higher during early adolescence and lower in adulthood. However, the levels of glutamatergic transmission onto CR-positive, non-fast spiking interneurons (CR/NFS) remain unchanged throughout adolescence. (B) In the adult PFC, the frequency of glutamatergic synaptic activity onto PV/FSI increases significantly in tandem with a marked upregulation of PV expression. No developmental changes are observed in glutamatergic transmission onto CR/NFS, yet there is a robust decrease of CR expression in adults. The identity of such glutamatergic inputs remains to be defined.