We performed a large population pharmacokinetic modeling analysis of the possible effects of renal impairment on steady-state plasma concentrations of rivastigmine and its metabolite, after rivastigmine patch and capsule treatment in patients with Alzheimer’s disease.

No correlation was observed between creatinine clearance or estimated glomerular filtration rate and plasma concentrations of rivastigmine or its metabolite, indicating that renal function did not impact steady-state plasma concentrations of rivastigmine or its metabolite.

Consequently, no dose adjustment in patients with renal impairment is required. This is a key finding allowing all Alzheimer’s disease and Parkinson’s disease dementia patients to benefit from most optimal therapeutic doses of rivastigmine, irrespective of their renal function status.