Table 1.

Binding of endocannabinoids and phytocannabinoids to the human CB₂ receptor

	K i (nM)	Model	References
Endocannabinoid
AEA	371	CHO cells	[8]
	1940	AtT-20 cells	[9]
	795	Sf9 cells	[10]
	3500	CHO cells	[10]
2-AG	949	Sf9 cells	[10]
	650	CHO cells	[10]
Dihomo-γ-LEA	857	AtT-20 cells	[9]
Oleamide	>100,000	HEK-293 cells	[11]
NADA	12,000b	Rat spleen	[12]
2-AG-ether	>3000a	COS-7 cells	[13]
Phytocannabinoid
∆9-THC	34.6	CHO cells	[8]
∆8-THC	39.3	Mouse spleen	[14]
CBN	96.3	CHO cells	[8]
	301	AtT-20 cells	[9]
CBD	2680	CHO cells	[8]
β-Caryophyllene	155	HEK293 cells	[15]

K _i values were obtained in function of [³H]CP 55,940 displacement unless indicated otherwise

NADA N-arachidonoyl-dopamine, CBN cannabinol

^a[³H]HU-243

^b[³H]WIN55212-2