Table 2.

CB₂ agonists and antagonists

	K i (nM)	Other targets	References
Agonist
AM 1241	3.4	TRPA1	[16, 17]
JWH 133	3.4	TRPV1	[18, 19]
GW 405833	3.6–3.92	–	[20]
JWH 015	13.8	–	[8]
HU 308	22.7	–	[21]
L-759,633	6.4	–	[22]
L-759,656	11.8	–	[22]
SER 601	6.3	–	[23]
GP 1a	0.037	–	[24]
GP 2a	7.6	–	[24]
CB 65	3.3	–	[25]
HU 210	0.061–0.52	CB1, GPR55, 5-HT2	[9, 26, 27]
CP 55,940	0.6–5.0	CB1, GPR55	[26, 28]
WIN 55, 212-2	62.3	CB1,TRPA1	[9, 17, 28]
Antagonist
SR144528	0.6–4.1	–	[22, 29]
AM 630	5.6–31.2	TRPA1	[22, 30]
JTE907	35.9	–	[31]

– This compound is not known to activate other receptors besides CB₂

TRP transient receptor potential ion channel