Table 5.

Effects of CB₂ agonists on immune cell functions

Cell type	Species	Agonist	Effects	References
Astrocytes	Human	WIN 55,212-2	↓ Nitric oxide ↓ TNF-α, IL-10, MCP-1 and CCL5	[126]
Dendritic cells	Mouse	∆9-THC	↑ NF-κB-dependent apoptosis	[127]
		GP1a	↓ MMP-9 ↓ Migration	[128]
Monocytes	Human	JWH-015	↓ CCL2 and CCL3-induced migration	[78]
		HU-308 JWH-133	↓ TNF-α-induced transendothelial migration	[129]
Macrophages	Human (monocyte-derived)	JWH-133	↓ Expression of 35 genes upregulated by LPS	[130]
		JWH-133 GP1a O-1966	↓ HIV-1 replication	[75]
	Mouse (RAW264.7)	WIN 55,212-2	↓ Reactive oxygen species	[131]
			↓ Nitric oxide	[132]
	Mouse (peritoneal)	∆9-THC	↓ RANTES-induced migration	[133]
		JWH-133	↑ IL-10 ↓ IL-12p40	[134]
	Mouse (clone 63)	∆9-THC	↓ Activation of CD4+ T cells	[59]
Mast cells	Rat (RBL-2H3)	WIN 55,212-2 CP 55,940	↓ β-Hexosaminidase release	[135]
Microglia	Human	WIN 55,212-2	↓ HIV-1 expression	[125]
	Rat	JWH-015	↓ LPS-induced TNF-α production ↓ Migration	[136]
Neutrophils	Mouse	JWH-133	↓ MIP-2α-induced migration	[137]
	Human	JWH-133	↓ TNF-α-induced MMP-9 release	[138]
Splenocytes	Human	∆9-THC	↓ Primary and secondary antibody formation	[109]
T cells	Human	∆9-THC	↓ Th2 cytokine production	[139]
	Human (Jurkat)	CP 55,940 WIN 55,212-2 JWH-015	↓ SDF-1-induced migration	[140]
	Mouse	O-1966	↓ NF-κB activation ↑ SOCS5 expression ↑ IL-10	[141]
CD8+ T cells	Human	JWH-015	↓ SDF-1-induced migration	[140]

CCL chemokine (C–C motif) ligand, NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells, MMP matrix metallopeptidase, MIP macrophage inflammatory protein, HIV human immunodeficiency virus, SOCS suppressor of cytokine signaling