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. Author manuscript; available in PMC: 2016 Oct 22.
Published in final edited form as: J Psychopharmacol. 2015 Jun 4;29(7):812–821. doi: 10.1177/0269881115586937

Figure 5.

Figure 5

Effects of buprenorphine (1mg/kg) and naltrexone (1mg/kg), alone or in combination, in the mouse novelty-induced hypophagia task. The latency to drink milk in both the home and novel cage environments is shown. (A) The SSRI fluoxetine (20 mg/kg) was administered as a positive control and the selective κ-antagonist norBNI (10 mg/kg) shown for comparison (n=10 per group). (B) The irreversible μ-antagonist CCAM (3 mg/kg) blocked the effects of buprenorphine (1 mg/kg) on latency to drink in the home cage, but not the novel cage (n=9 per group). Data are mean ± SEM. *p< 0.05, **p< 0.01 and ***p< 0.001 compared to saline. #p< 0.05 and ###p< 0.001 for novel cage comparison to home cage. ^^^p< 0.001 compared to buprenorphine alone.