Table 2.
PITX2 mRNA Expression in Left Atrial Appendages From AF Ablation Patients∗
| Risk Alleles | 25% IQR | Median | 75% IQR | Mean | SEM | No. of Patients |
|---|---|---|---|---|---|---|
| 0 | 3.22 | 3.69 | 5.22 | 4.04 | 0.6 | 3 |
| 1 | 2.96 | 4.25 | 6.25 | 4.54 | 0.5 | 13 |
| 2 | 2.65 | 3.78 | 4.75 | 3.94 | 0.3 | 22 |
| 3 | 2.74 | 3.72 | 4.92 | 3.83 | 0.4 | 17 |
| 4 | 3.00 | 4.29 | 5.41 | 4.39 | 0.5 | 10 |
| 5 | 1.96 | 2.66 | 4.66 | 3.10 | 0.7 | 4 |
| 6 | 4.95 | 4.95 | 4.95 | 4.95 | 0.0 | 1 |
IQR = interquartile range; LA = left atrium; other abbreviations as in Table 1.
∗
This dataset was grouped according to the number of risk single nucleotide polymorphism (SNP) alleles for AF on chromosome 4q25 (rs2200733, SNP2 rs6838973, rs1448818 [13]). Although PITX2 mRNA is numerically lower in patients with 5 or 6 risk alleles, we did not find a PITX2 mRNA gradient according to AF risk.