Table 3.
Effect of Flecainide on Refractoriness and Repolarization in Mouse Hearts
| Paced CL, ms | Wild-Type |
Pitx2c+/– |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 120 |
100 |
80 |
120 |
100 |
80 |
|||||||
| Baseline | Flecainide | Baseline | Flecainide | Baseline | Flecainide | Baseline | Flecainide | Baseline | Flecainide | Baseline | Flecainide | |
| LA ERP, ms | ||||||||||||
| 23.5 ± 2.3 (11) | 29.8 ± 3.0 (11) | 22.2 ± 2.1 (11) | 29.6 ± 3.3 (11) | 21.9 ± 2.4 (10) | 28.7 ± 3.5∗ (10) | 30.5 ± 2.4 (11) | 38.5 ± 3.3∗ (11) | 28.0 ± 2.3 (13) | 40.2 ± 2.8∗ (13) | 27.5 ± 2.5 (13) | 41.2 ± 3.0∗† (13) | |
| LA monophasic APD, ms | ||||||||||||
| APD50 | 10.2 ± 1.3 (8) | 14.5 ± 1.7 (8) | 10.8 ± 1 (8) | 11.9 ± 1.6 (8) | 10.4 ± 0.7 (7) | 12.0 ± 1.1 (7) | 12.4 ± 1.1 (15) | 14.4 ± 1.3 (15) | 11.5 ± 1.0 (15) | 12.4 ± 1.1 (15) | 10.6 ± 0.9 (11) | 10.3 ± 1.0 (11) |
| APD70 | 17.8 ± 2.2 (9) | 23 ± 2.1 (9) | 18.4 ± 1.6 (9) | 18.7 ± 2.2 (9) | 18.1 ± 1.2 (8) | 18.1 ± 1.9 (8) | 18.0 ± 1.6 (15) | 19.2 ± 1.8 (15) | 16.0 ± 1.4 (13) | 16.2 ± 1.4 (13) | 14.9 ± 1.0† (10) | 13.1 ± 0.7 (10) |
| APD90 | 31.3 ± 3.0 (8) | 37.4 ± 2.8 (8) | 31.5 ± 2.5 (9) | 29.9 ± 2.9 (9) | 31.0 ± 1.4 (8) | 28.4 ± 2.7 (8) | 28.3 ± 2.2 (13) | 29.9 ± 2.2 (13) | 27.4 ± 2.2 (13) | 26.6 ± 1.5 (13) | 26.8 ± 1.7 (10) | 23.1 ± 1.4 (10) |
| LA transmembrane APD, ms | ||||||||||||
| APD30 | 4.5 ± 0.1 (30) | 5.5 ± 0.3 (22) | 4.5 ± 0.1 (30) | 5.4 ± 0.3 (22) | 4.4 ± 0.1 (30) | 5.2 ± 0.3 (22) | 4.0 ± 0.1 (31) | 4.7 ± 0.2 (24) | 3.9 ± 0.1 (31) | 4.6 ± 0.2 (24) | 3.8 ± 0.1† (31) | 4.4 ± 0.2 (24) |
| APD50 | 6.7 ± 0.2 (30) | 8.2 ± 0.5 (22) | 6.6 ± 0.2 (30) | 8.0 ± 0.4 (22) | 6.4 ± 0.2 (30) | 7.8 ± 0.5 (22) | 5.9 ± 0.2 (31) | 7.1 ± 0.4 (24) | 5.7 ± 0.2 (31) | 7.0 ± 0.4 (24) | 5.6 ± 0.2† (31) | 6.7 ± 0.3 (24) |
| APD70 | 10.5 ± 0.4 (30) | 12.7 ± 0.8 (22) | 10.1 ± 0.4 (30) | 12.1 ± 0.7 (22) | 9.6 ± 0.4 (30) | 11.8 ± 0.7 (22) | 8.9 ± 0.4 (31) | 10.7 ± 0.6 (24) | 8.6 ± 0.4 (31) | 10.3 ± 0.6 (24) | 8.3 ± 0.3† (31) | 9.8 ± 0.5 (24) |
| APD90 | 20.9 ± 1.0 (30) | 23.4 ± 1.5 (22) | 19.9 ± 0.9 (30) | 22.2 ± 1.4 (22) | 18.4 ± 0.8 (30) | 21.6 ± 1.3 (22) | 17.6 ± 0.9 (31) | 20.3 ± 1.1 (24) | 16.5 ± 0.8 (31) | 19.2 ± 1.0 (24) | 15.7 ± 0.8† (31) | 17.9 ± 0.9 (24) |
| LA optical APD, ms | ||||||||||||
| APD30 | 6.1 ± 0.3 (10) | 7.3 ± 0.6 (6) | 6.4 ± 0.8 (10) | 5.9 ± 1.0 (6) | 6.1 ± 0.4 (10) | 6.9 ± 1.3 (6) | 4.9 ± 0.4 (10) | 7.7 ± 0.9 (8) | 4.6 ± 0.3 (10) | 5.4 ± 0.7 (8) | 4.3 ± 0.4† (10) | 5.7 ± 0.7 (8) |
| APD50 | 8.5 ± 0.6 (10) | 10.7 ± 1.2 (6) | 8.9 ± 1.1 (10) | 8.5 ± 1.2 (6) | 8.3 ± 0.7 (10) | 10.3 ± 1.8 (6) | 6.9 ± 0.4 (10) | 10.0 ± 1.0 (8) | 6.6 ± 0.4 (10) | 8.1 ± 0.9 (8) | 6.1 ± 0.4† (10) | 8.0 ± 0.9 (8) |
| APD70 | 11.7 ± 1.2 (10) | 15.0 ± 2.1 (6) | 12.5 ± 1.5 (10) | 12.8 ± 1.7 (6) | 11.5 ± 1.1 (10) | 14.4 ± 2.5 (6) | 9.4 ± 0.0 (10) | 13.3 ± 1.2 (8) | 9.4 ± 0.6 (10) | 11.6 ± 1.5 (8) | 9.1 ± 0.5† (10) | 11.2 ± 1.2 (8) |