Table 4.
Electrophysiological Effects of Sotalol
| Paced CL, ms | Wild-Type |
Pitx2c+/– |
||||||
|---|---|---|---|---|---|---|---|---|
|
120 |
100 |
120 |
100 |
|||||
| Baseline | Sotalol | Baseline | Sotalol | Baseline | Sotalol | Baseline | Sotalol | |
| LA ERP, ms | ||||||||
| 38.7 ± 7.8 (7) | 33.9 ± 6.3 (7) | 32.2 ± 6.1 (6) | 29.2 ± 5.3 (6) | 39.3 ± 4.0 (4) | 26.8 ± 3.5 (4) | 37.0 ± 5.7 (4) | 24.0 ± 3.7 (4) | |
| LA APD, ms | ||||||||
| APD50 | 11.5 ± 1.2 (9) | 13.4 ± 1.2 (9) | 10.9 ± 2.0 (7) | 12.2 ± 1.3 (7) | 10.8 ± 1.1 (7) | 11.2 ± 1.0 (7) | 8.3 ± 0.9 (4) | 11.1 ± 1.7 (4) |
| APD70 | 17.6 ± 2.2 (9) | 20.0 ± 1.9 (9) | 16.0 ± 1.3 (7) | 18.2 ± 2.3 (7) | 16.5 ± 1.6 (7) | 17.3 ± 1.2 (7) | 13.0 ± 1.5 (4) | 17.0 ± 1.9 (4) |
| APD90 | 30.7 ± 3.2 (9) | 33.5 ± 2.7 (9) | 29.0 ± 1.9 (7) | 30.9 ± 3.2 (7) | 29.7 ± 2.7 (7) | 31.2 ± 2.0 (7) | 23.8 ± 2.8 (4) | 29.6 ± 2.9 (4) |