Table 5.

Electrophysiological Effects of Reduced Sodium Conductance in a Human Atrial Model

Paced CL, ms	Wild-Type Model		Pitx2c Deficiency Model
	500	1,000	500	1,000
RMP, mV
gNa, %
100	-79.92	-81.28	-77.90	-79.61
50	-79.60	-81.12	-77.33	-79.37
40	-79.43	-81.01	-76.99	-79.23
APD at repolarization to -60 mV, ms
gNa, %
100	217	253	206	226
50	239	266	233	239
40	248	273	245	245
ERP, ms
gNa, %
100	266	301	261	280
50	308	335	316	320
40	327	352	342	339
PRR, ms
gNa, %
100	49	48	55	54
50	69	69	83	81
40	79	79	97	94
Conduction velocity, cm/s
gNa, %
100	49.5	50.0	50.3	50.5
50	36.9	37.0	37.5	37.5
40	32.9	32.7	33.0	33.1

g_Na = reduced sodium conductance; PRR = post-repolarization refractoriness; RMP = resting membrane potential; other abbreviations as in Table 3.