Table 6.
Electrical Activation Time and Conduction Velocity in Isolated Atria in the Presence of Flecainide (1 μmol/l)
| Wild-Type | Pitx2c+/– | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Paced CL, ms | 1,000 | 300 | 120 | 100 | 80 | 1,000 | 300 | 120 | 100 | 80 |
| Activation time (isolated left atrium), ms | 6 ± 0.3 (22) | 6 ± 0.3 (22) | 9 ± 0.5 (22) | 12 ± 1.0 (22) | 16 ± 1.4 (22) | 6 ± 0.2 (24) | 7 ± 0.3 (24) | 12 ± 0.9 (24) | 13 ± 0.9 (24) | 18 ± 1.2 (24) |
| Conduction velocity (optical mapping), cm/s | — | 30 ± 1.8 (8) | 25 ± 2.4 (8) | 25 ± 1.9 (8) | 23 ± 1.9 (8) | — | 29 ± 1.5 (8) | 26 ± 1.6 (8) | 25 ± 1.6 (8) | 23 ± 1.6 (8) |
Values are mean ± SEM (number of atria).
— = not applicable; other abbreviations as in Table 3.