TABLE 2.

Characterization of different H37Rv dprE1 mutants^a

Mutation	Codon	Colony size	Presence of BTZ in plate from which colonies were picked	Mutation(s) identified by sequencing	BTZ043 MIC (μg/ml)	RIF MIC (μg/ml)
C387	TGC (WT)				0.0008	0.0016
C387S	TCC	Normal	BTZ043	C387S	≥10	0.0016
C387A	GCC	Normal	BTZ043	C387A	>10	0.0016
C387T	AAT	Normal	BTZ043	C387T	>10	0.0016
C387G	GGC	Small		C387G	Undet.	Undet.
		Normal		C387G V388I	5	0.0008
C387N	ACC	Small		C387N	1.25	0.0008
		Normal		C387T*	>10	0.0016

^aRIF, rifampin; Undet., undetermined. * indicates the C387T mutation with an ACT codon.