TABLE 1.
Sensitivity of each strain to plumbagin, meropenem, and clofazimine by the disk diffusion method
| Drug (concn) | Inhibition zone diam (mm) for wild-type strain |
ppk2::Tn mutant |
ppk2::Tn Comp strain |
ppx1::Tn mutant |
ppx1::Tn Comp strain |
||||
|---|---|---|---|---|---|---|---|---|---|
| Inhibition zone diam (mm) | P value | Inhibition zone diam (mm) | P value | Inhibition zone diam (mm) | P value | Inhibition zone diam (mm) | P value | ||
| Plumbagin | |||||||||
| 20 mM | 25 ± 1.7 | 32.7 ± 4.1 | 0.042 | 24.3 ± 0.6 | 0.561 | 25.7 ± 2.1 | 0.692 | 23.3 ± 0.6 | 0.189 |
| 100 mM | 44 ± 1 | 49.3 ± 1.2 | 0.004 | 45.3 ± 4.2 | 0.618 | 47.3 ± 2.5 | 0.100 | 40.7 ± 2.3 | 0.083 |
| Meropenem | |||||||||
| 10 μg/ml | 17.4 ± 1.2 | 24 ± 2 | 0.007 | 20.6 ± 1.2 | 0.024 | 19.4 ± 2.4 | 0.251 | 16 ± 0 | 0.116 |
| 20 μg/ml | 26.6 ± 1.154 | 29.3 ± 1.2 | 0.047 | 31.3 ± 3.1 | 0.069 | 31.3 ± 3.2 | 0.077 | 32.6 ± 4.9 | 0.110 |
| Clofazimine (10 μg/ml) | 18.3 ± 0.57 | 18.6 ± 2.3 | 0.820 | 17.33 ± 1.2 | 0.251 | 21 ± 1 | 0.006 | 20.3 ± 1.2 | 0.055 |