TABLE 2.
Final ceftolozane population pharmacokinetic parameter estimates for 20 adults with CF
| Pharmacokinetic parametera | Mean | SD | Median |
|---|---|---|---|
| Observed | |||
| Vc (liters) | 7.51 | 2.05 | 8.11 |
| CLi (liters/h) | 2.00 | 0.85 | 2.21 |
| CLs (liters/h) | 0.02 | 0.01 | 0.02 |
| Kcp (h−1) | 0.87 | 1.98 | 0.23 |
| Kpc (h−1) | 0.66 | 0.46 | 0.48 |
| Calculated | |||
| CL (liters/h) | 4.76 | 1.13 | 4.84 |
| t1/2 (h) | 2.87 | 0.97 | 2.91 |
a
Vc, volume of central compartment; CLi and CLs, clearance intercept term and clearance slope term, respectively, where total body clearance (CL) = CLi + (CLs × CLCR) and CLCR is creatinine clearance (ml/min) calculated with the Cockcroft-Gault equation; Kcp and Kpc, intercompartment transfer constants; t1/2, half life.