TABLE 1.

Validation compounds and chemical and target information for the selected validation compounds

Compound IDa	Putative target/mode of actionb	Compound class	Reference
ELQ-300*	bc1 complex	4(1H)-Quinolone	84
Antimycin A	bc1 complex (Qi site)	Other	119
Atovaquone	bc1 complex (Qo site)	Naphthoquinone	61
Myxothiazol	bc1 complex (Qo site)	Other	120
P218*	DHFR	2,4-Diaminopyrimidine	89
Pyrimethamine	DHFR	Antifolate	87
WR99210	DHFR	Antifolate	88
DSM265*	DHODH	Triazolopyrimidine	86
DSM1	DHODH	Triazolopyrimidine	121
2-Deoxyglucose	Hexokinase and phosphoglucoisomerase	Other	122
OZ277*	Peroxide mediated	Trioxane	123
OZ439*	Peroxide mediated	Trioxane	95
KAE609*	PfATP4	Sprioindolone	36
(+)-SJ733*	PfATP4	Dihydroisoquinolone	64
KAF246	PfATP4	Spiroindolone	37
KAF156*	PfCARL	Imidazolopiperazine	39
Chloroquine	PfCRT	4-Aminoquinonlone	124
MMV390048*	PfPI4K	Aminopyridine	91
DDD498*	Translation elongation factor 2	Quinoline-4-carboxamide	40
AZ412*	Vacuolar ATP synthase (V-type H+-ATPase) subunit D	Triaminopyrimidine	92

^aMMV lead compounds are denoted with an asterisk.

^bDHFR, dihydrofolate reductase; DHODH, dihydroorotate dehydrogenase.