FIG 2.

Fluconazole and caspofungin inhibit C. albicans dissemination from the GI tract of an immunocompromised host. Mice were infected with 6 × 10⁷ cells of a wild-type C. albicans strain, administered antifungals, immunosuppressed, and sacrificed as described in the legend of Fig. 1A. (A) Mean fungal burdens (± standard errors of the means) in feces of the indicated groups of mice taken at the time points shown. (B) Fungal burdens in gastrointestinal organs from the indicated groups of mice sacrificed at the indicated time points (bars indicate medians) (n = 5 [infected groups on day 14 {D14} or day 21] or n = 10 [all other groups]). (C) Fungal burdens in systemic organs from the indicated groups of mice sacrificed at the indicated time points (bars indicate medians) (n = 5 [infected groups on day 14 or day 21] or n = 10 [all other groups]). No fungal burdens were observed for the uninfected group. CSP, 1 mg/kg caspofungin; FLU, 5 mg/kg fluconazole; Immuno, immunocompromised.