FIG 3.

C. albicans dissemination from the GI tract reduces survival of an immunocompromised host. Mice were infected with 4.2 × 10⁷ cells of a wild-type C. albicans strain as described in the legend of Fig. 1B. Four consecutive doses of cyclophosphamide (150 mg/kg) and prednisolone (65 mg/kg) were administered to both infected and uninfected control groups at the indicated time points (down arrows), and survival was monitored for 30 days (n = 9 [infected group] or n = 10 [uninfected group]). Based on a log rank analysis, we observed a statistically significant difference between the infected and uninfected groups (P = 0.0002).