TABLE 5.
Multivariate comparison of 2-month culture positivity among patients with unsuspected MDR-TB receiving standard first-line antituberculous therapy by PZA resistance assay and the consensus gold standarda
| Variable | Adjusted OR (95% CI)b |
|---|---|
| Baseline PZA resistance (Wayne method) | |
| Yes | 2.34 (0.90–6.08) |
| No | Reference |
| Baseline PZA resistance (MGIT) | |
| Yes | 3.43 (1.28–9.15) |
| No | Reference |
| Baseline PZA resistance (pncA sequencing) | |
| Yes | 2.12 (0.79–5.72) |
| No | Reference |
| Baseline PZA resistance (consensus) | |
| Yes | 1.95 (0.74–5.11) |
| No | Reference |
a
CI, confidence interval; MDR-TB, multidrug-resistant tuberculosis; MGIT, mycobacteria growth indicator tube; OR, odds ratio; PZA, pyrazinamide. Data are for a total of 116 patients. Two (1.7%) patients had a missing 2-month culture result due to a contaminated sample, and three (2.5%) patients had a missing 2-month culture result for an unknown reason.
b
P values of <0.05 are shown in bold, and P values of ≥0.05 and <0.1 are shown in italics. All multivariate models are adjusted for age, sex, alcohol use, and baseline EMB resistance.