TABLE 1.
MBC, MIC, and MBEC data for P. aeruginosa and S. aureusa
| Strain and antibiotic | Growth data (μg/ml) |
||
|---|---|---|---|
| Planktonic MIC | Biofilmb |
||
| MBEC | Model MBC | ||
| P. aeruginosa PA01 | |||
| Tobramycin | 1 | 8 | 252 |
| Gentamicin | 8 | 31.3 | 532 |
| MRSA ATCC 6538 | |||
| Gentamicin | 512 | >512 | >2,500 |
| Vancomycin | 2 | 512 | >2,100 |
| Gentamicin-vancomycin | 0.12/0.5 | 16/66.7 | >2,400/6,590 |
a
MIC and MBEC data for P. aeruginosa and S. aureus were compared to MBC data for local concentrations of antibiotics determined in the collagen phase of the wound model.
b
Where “>” is used, the highest concentration of antibiotics used in the MBEC or detected in the collagen is cited but bacterial growth was still present. Each assay was set up with n = 8 and repeated on two different days.