TABLE 2.
A. baumannii time-kill assay responses of isolates against which drug combinations were synergistic by the checkerboard method
Combination and isolate | 24-h log killinga | Regrowth | 24-h synergy |
---|---|---|---|
Minocycline-colistin | |||
12 | −6.1 | No | No |
30 | −5.9 | No | Yes |
31 | −5.5 | No | Yes |
34 | −6 | No | Yes |
40 | −6 | No | Yes |
Tigecycline-amikacin | |||
18 | 2.1 | No | No |
31 | 0.5 | No | No |
Minocycline-amikacin, 17 | −1.1 | Yes | Yes |
Minocycline-doripenem | |||
17 | −2.6 | No | No |
52 | −1.1 | No | Yes |
Doripenem-tigecycline | |||
17 | −2.1 | No | Yes |
31 | 0.1 | No | No |
53 | 1.4 | No | No |
Doripenem-colistin | |||
24 | −5.9 | No | Yes |
31 | −3.9 | No | No |
33 | −1.2 | No | No |
69 | −1.4 | No | Yes |
Doripenem-colistin-minocycline | |||
2 | −1.3 | No | No |
8 | −0.8 | No | No |
12 | −3.3 | No | Yes |
24 | −6.1 | No | Yes |
28 | −0.9 | No | Yes |
Doripenem-colistin-tigecycline | |||
12 | −0.3 | No | No |
69 | −5.7 | No | Yes |
Bold values indicate a bactericidal effect.