TABLE 2.
A. baumannii time-kill assay responses of isolates against which drug combinations were synergistic by the checkerboard method
| Combination and isolate | 24-h log killinga | Regrowth | 24-h synergy |
|---|---|---|---|
| Minocycline-colistin | |||
| 12 | −6.1 | No | No |
| 30 | −5.9 | No | Yes |
| 31 | −5.5 | No | Yes |
| 34 | −6 | No | Yes |
| 40 | −6 | No | Yes |
| Tigecycline-amikacin | |||
| 18 | 2.1 | No | No |
| 31 | 0.5 | No | No |
| Minocycline-amikacin, 17 | −1.1 | Yes | Yes |
| Minocycline-doripenem | |||
| 17 | −2.6 | No | No |
| 52 | −1.1 | No | Yes |
| Doripenem-tigecycline | |||
| 17 | −2.1 | No | Yes |
| 31 | 0.1 | No | No |
| 53 | 1.4 | No | No |
| Doripenem-colistin | |||
| 24 | −5.9 | No | Yes |
| 31 | −3.9 | No | No |
| 33 | −1.2 | No | No |
| 69 | −1.4 | No | Yes |
| Doripenem-colistin-minocycline | |||
| 2 | −1.3 | No | No |
| 8 | −0.8 | No | No |
| 12 | −3.3 | No | Yes |
| 24 | −6.1 | No | Yes |
| 28 | −0.9 | No | Yes |
| Doripenem-colistin-tigecycline | |||
| 12 | −0.3 | No | No |
| 69 | −5.7 | No | Yes |
Bold values indicate a bactericidal effect.