TABLE 1.
Patient characteristics and voriconazole concentrations in aqueous humors
| Study arm and patient no. (time before surgery) | Sex | Age (yr) | Concn. of voriconazole in aqueous humor (mg/liter) | Postdose sampling time (min) |
|---|---|---|---|---|
| Arm 1 (20 min) | ||||
| 1 | Male | 86 | 4.1 | 22 |
| 2 | Male | 44 | 3.2 | 20 |
| 3 | Female | 71 | 3.4 | 20 |
| 4 | Male | 79 | 1.9 | 25 |
| 5 | Male | 69 | 1.1 | 17 |
| Arm 2 (40 min) | ||||
| 1 | Male | 82 | 2.1 | 52 |
| 2 | Male | 75 | 2.6 | 44 |
| 3 | Male | 66 | 3.1 | 41 |
| 4 | Male | 72 | 3.3 | 39 |
| 5 | Male | 66 | 3.4 | 45 |
| Arm 3 (60 min) | ||||
| 1 | Female | 90 | 5.1 | 56 |
| 2 | Female | 74 | 1.7 | 58 |
| 3 | Male | 72 | 1.9 | 65 |
| 4 | Female | 77 | 3.3 | 55 |
| 5 | Female | 74 | 1.2 | 58 |
| Arm 4 (80 min) | ||||
| 1 | Male | 72 | 0.9 | 87 |
| 2 | Male | 68 | 2.3 | 80 |
| 3 | Male | 52 | 2.0 | 80 |
| 4 | Female | 51 | 2.0 | 78 |
| 5 | Female | 77 | 0.9 | 95 |