Table 5.

Predictor of HOMA index at study completion by unadjusted and multivariable adjusted spline regression analyses

Predictor of HOMA index at study completion (further elaborations)
Variable	B-coef	Standard Error	P value
Unadjusted
- Serum bicarbonate <28 mmol/l at follow-up	−4.6008	1.1804	0.00015
- Serum bicarbonate ≥28 mmol/l at follow-up	1.9360	1.0270	0.06146
Adjusted for treatment, serum bicarbonate greater/equal or lower than 28 mmol/l
- Treatment (yes vs no)	−0.3482	0.4757	0.4654
- Serum bicarbonate <28 mmol/l at follow-up	−3.6980	1.7085	0.0321
- Serum bicarbonate ≥28 mmol/l at follow-up	2.2055	1.0926	0.0454

Serum bicarbonate is used as a continuous variable and divided according to ≥ 28 mmol/l (knot). The HOMA-serum bicarbonate levels relationship changes for values of serum bicarbonate greater equal than 28 mmol/l