Table 4.
The percentage of maximum possible effect (%MPE) of MECC in tail immersion test
| Treatment | Dose (mg/kg) | %MPE | ||||
|---|---|---|---|---|---|---|
| 30 min | 45 min | 60 min | 90 min | 120 min | ||
| Vehicle | - | 1.95 ± 1.15 | 0.87 ± 0.83 | 0.10 ± 1.44 | 0.32 ± 1.07 | 0.71 ± 1.20 |
| NLX | 2 (i.p.) | 1.12 ± 1.18 | 1.74 ± 1.99 | 1.25 ± 1.33 | 2.43 ± 1.42 | 2.09 ± 0.74 |
| MECC | 50 | 4.35 ± 0.57 | 6.55 ± 0.97 | 8.99 ± 1.60 | 10.77 ± 1.38* | 5.40 ± 1.56 |
| MECC | 100 | 5.04 ± 1.18 | 8.57 ± 2.17 | 10.28 ± 2.11 | 10.05 ± 2.31* | 9.88 ± 1.88 |
| MECC | 200 | 6.15 ± 1.56 | 11.36 ± 1.65 | 14.65 ± 1.71* | 16.12 ± 0.58* | 14.39 ± 1.32* |
| MECC | 400 | 9.97 ± 1.02* | 14.46 ± 0.95* | 19.51 ± 0.56* | 22.60 ± 1.33* | 17.91 ± 1.79* |
| Morphine | 5 (i.p.) | 36.98 ± 1.39* | 50.92 ± 4.19* | 56.30 ± 2.72* | 35.65 ± 2.07* | 29.17 ± 3.41* |
Each value is presented as the mean ± SEM (n = 5). MECC = Methanol extract of C. cristata; NLX = Naloxone. * represents p < 0.001, compared with the control group (Dunnett’s test)