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Pik3cb as a crucial direct target of Yap that links Hippo-Yap to PI3K-AKT signaling activation and regulates cardiomyocyte proliferation and survival. Dephosphorylated Yap/TAZ translocates into nuclear and directly activates target gene Pik3cb expression with several transcription factors (TEA-domain sequence-specific DNA-binding proteins). Pik3cb activation downstream of Yap promotes cardiomyocyte proliferation and survival by stimulating AKT activation.
