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. Author manuscript; available in PMC: 2016 Oct 23.
Published in final edited form as: Radiat Res. 2009 Oct;172(4):481–492. doi: 10.1667/RR1647.1

FIG. 2.

FIG. 2

Amelioration of radiation-induced injury of jejunum in wild-type (WT) and DNase I knockout (KO) mice treated with or without Zn-DIPS. Panel A: Representative images of the radiation-induced DNA fragmentation (TUNEL, green staining) and reduced cell numbers (DAPI, blue color) in villi and crypts. TUNEL-positive cells are present in the epithelium and stroma. Villi of wild-type animals often had interruptions of epithelial line (gaps) at 16 h after irradiation. Scale bar 20 mm. Quantification of TUNEL (panels B, D, F) and cell numbers (panels C, E, G) was performed in the epithelial (panels B, C) and stromal (panels D, E) parts of villi and in the crypt part of the intestine (panels F, G). *P < 0.05 compared to control mice of same genotype, #P < 0.05 compared to irradiated wild-type mice for the same time/treatment, ¶P < 0.05 compared to irradiated mouse of the same genotype at 16 h. n = 6–12 per group.