Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 22;11:69. doi: 10.1186/s13024-016-0132-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 7 — Motor function analysis before and after sciatic nerve injury in progranulin deficient, control and progranulin-overexpressing mice. Behavioral data are the means ± SD of n = 8–12 mice per group. a Time courses of the running times on a constant speed (Grn^−/−) or accelerating RotaRod (SLICK-Grn-OE, with tamoxifen) before and after spared nerve injury or crush nerve injury of the sciatic nerve, respectively. Asterisks show significant differences between genotypes (rm-ANOVA and subsequent t-tests between genotypes, * P < 0.05). b Time course of voluntary wheel running before and after spared injury of the left sciatic nerve in Grn^−/− and Grn^+/+ mice. Running times briefly dropped after nerve injury but rapidly recovered. After nerve injury, Grn^−/− avoided right turns and the right/left ratio significantly differed between genotypes (* P < 0.05; rm-ANOVA and subsequent 2-tailed t-tests between genotypes). c Time course of the struggling times in the tail suspension test (TST) before and after crush injury of the sciatic nerve. Struggling decreased over time in both groups. The decrease was stronger in Grn^−/− mice (* P < 0.05; rm-ANOVA, posthoc 2-sided t-tests versus control, Dunnett adjustment of alpha).d MotoRater analysis of locomotion in an over-ground walking task in SLICK-Grn-OE (with tamoxifen) and SLICK-Grn mice (without tamoxifen, control). The upper panel shows the time courses of the iliac crest height and hind paw inter-step distances before and after crush injury of the sciatic nerve (means ± SD). The lower box plots show the time course of coordination represented by the ratios of the diagonals of the ‘left hind to right front’ paw (LH-RF) and vice versa (LF-RH) for the steps of mid lengths (left) and the long steps (right). The line is the median, the box represents the interquartile range, the whiskers show 5 –95 % percentiles ( *P < 0.05; rm-ANOVA, subsequent 2-tailed t-tests between genotypes)