Table 2.
Quantitative imaging variables compared between symptomatic PSEN1 mutation carriers with and without SP by two-sided t-tests. *Microhemorrhage counts greater than 100 were quantified as 100. Comparisons were made using Mann-Whitney U tests.
| PSEN1 mutation carriers with SP (n = 3) | PSEN1 mutation carriers without SP (n = 7) | ||
|---|---|---|---|
| Mean cerebellar volume mm3 (s.d.) | 122,053 (4,708) | 128,625 (17,892) | p = 1.00 |
| Mean caudate volume mm3 (s.d.) | 6,389 (784) | 6,854 (620) | p = 0.38 |
| Mean putamen volume mm3 (s.d.) | 8,617 (1,534) | 9,248 (1128) | p = 0.67 |
| Mean pallidum volume mm3 (s.d.) | 2,908 (124) | 3,116 (218) | p = 0.27 |
| Mean amygdala volume mm3 (s.d.) | 2,787 (672) | 2,598 (652) | p = 0.83 |
| Mean right hippocampal volume mm3 (s.d.) | 2,982 (331) | 3,146 (720) | p = 0.67 |
| Mean left hippocampal volume mm3 (s.d.) | 3,000 (215) | 3,112 (639) | p = 0.83 |
| Mean occipital cortex thickness mm (s.d.) | 1.72 (0.05) | 1.90 (0.15) | p = 0.12 |
| Mean temporal cortex thickness mm (s.d.) | 2.66 (0.33) | 2.83 (0.16) | p = 0.38 |
| Mean parietal cortex thickness mm (s.d.) | 2.05 (0.06) | 2.18 (0.22) | p = 0.67 |
| Mean frontal cortex thickness mm (s.d.) | 2.39 (0.11) | 2.44 (0.09) | p = 0.67 |
| Mean WMH volume – mm3 (s.d.) | 17,978 (3,651) | 9,491 (15,954) (n = 5) | p = 0.25 |
| Mean Fazekas score (s.d.) | 2.0 (1.0) | 1.2 (1.3) (n = 5) | p = 0.39 |
| # microhemorrhages* | 66.7 (57.7) | 12.2 (29.8) (n = 6) | p = 0.17 |