Table 2.

Univariate and multivariate analysis by Cox proportional hazards model in adenocarcinoma patients of Yale cohorts A and B. EGFR:GRB2 PLA is an independent prognostic marker of survival. Gender and stage were independent prognostic markers only in Yale cohort A.

Yale Cohort A
		Univariate Analysis			Multivariate Analysis
	Variables	Hazard Ratio 95% CI		P value	Hazard Ratio 95% CI		P value
Age	<70 yr vs ≥70yr	1.178	0.652 – 2.131	0.587	1.01	0.516 – 1.974	0.978
Gender	Female vs Male	2.336	1.297 – 4.205	*0.005	2.826	1.524 – 5.242	*0.001
Stage	I–IIIA vs IIIB–IV	4.689	1.836 – 11.976	*0.001	9.599	2.94 – 31.342	*<0.000
Smoking Status	Never Smoker vs Former/Current Smoker	1.22	0.581 – 2.564	0.599	1.127	0.536 – 2.372	0.752
EGFR:GRB2 PLA	1st quartile vs 2nd, 3rd, 4th quartile	0.486	0.263 – 0.896	*0.021	0.439	0.229 – 0.841	*0.013

Yale Cohort B
		Univariate Analysis			Multivariate Analysis
	Variables	Hazard Ratio 95% CI		P value	Hazard Ratio 95% CI		P value
Age	<70 yr vs ≥70yr	0.76	0.418 – 1.383	0.369	0.732	0.387 – 1.386	0.338
Gender	Female vs Male	1.631	0.93 – 2.859	0.088	1.321	0.709 – 2.461	0.381
Stage	I–IIIA vs IIIB–IV	1.746	0.84 – 3.630	0.136	1.577	0.716 – 3.471	0.258
Smoking Status	Never Smoker vs Former/Current Smoker	1.483	0.531 – 4.137	0.452	1.109	0.383 – 3.208	0.849
EGFR:GRB2 PLA	1st quartile vs 2nd, 3rd, 4th quartile	0.466	0.26 – 0.834	*0.01	0.44	0.234 – 0.829	*0.011