Table 2.
Expression of IL-1β signaling and processing genes in 5-aza and LPS-treated primary cultured microglia.
| Vehicle | AZA | p-value | |||||
|---|---|---|---|---|---|---|---|
| Gene | Control | LPS | Control | LPS | AZA | LPS | AZA × LPS |
| Casp1 | 1.04±0.12 | 3.09±0.48 | 0.72±0.05 | 2.67±0.17 | 0.074* | <0.0001* | 0.307 |
| IL-1Rn | 1.10±0.18 | 32.73±6.79 | 0.95±0.11 | 26.55±2.86 | 0.632 | <0.0001* | 0.962 |
| NLRP3 | 1.06±0.15 | 42.22±9.60 | 0.68±0.13 | 34.07±2.06 | 0.079* | <0.0001* | 0.285 |
Primary cultured microglia were treated with 5-aza for 24 h and/or LPS for 4 h. Bars represent the mean ± SEM (n = 3–4).
*
indicates p<0.1.