Table 4.
Diabetes score sheet developed from participants in the Insulin Resistance Atherosclerosis Study
| A. β coefficients and score points | ||
|---|---|---|
| β coefficient | Score sheet | |
| Intercept | − 3.36 | - |
| Age ≥60 years | 0.61 | 1 |
| Female gender | 0.55 | 1 |
| Impaired fasting glucose | 1.26 | 1.5 |
| Obesity (BMI ≥30 kg/m2) | 0.75 | 1 |
| ALT ≥0.43 μkat/l | 1.05 | 1.5 |
| B. Predictive discrimination | ||
|---|---|---|
| Prediction model | Total score | |
| Area under the ROC | 0.761 | 0.756 |
| C. Diabetes Prediction Sheet | ||
|---|---|---|
| Total score | Yearly risk of diabetes (%) | Relative risk |
| 0–1 | 0.5 | Reference |
| 1.5–2.5 | 3 | 6 |
| 3–4 | 6 | 9 |
| ≥ 4.5 | 9 | 18 |
ALT, alanine aminotransferase; ROC, receiver-operating curve.
We used a forward selection procedure to develop a parsimonious and accurate prediction model. Level of significance to entry and stay were <0.25 and <0.05, respectively. The prediction model included the following variables: age categories (40–49, 50–59, 60–69 years), sex, ethnicity (Hispanic, African-American and non-Hispanic white), IFG (yes vs. no), BMI categories (<25, 25–29.9, ≥30 kg/m2), and ALT [≥0.43 vs. <0.43 μkat/l (≥26 vs. 26 IU/l)].