Table 4.

Effects of various bariatric procedures on diabetic parameters and serum bile acid concentrations

Patients	Type of bariatric procedure	Time interval from surgery to examination	Effect of surgery on diabetic parameters	Effect of surgery on serum bile acid concentrations	Ref.
Morbidly obese, n = 10	LAGB	Various (after losing 20% of body weight)	Not presented	Decreased fasting BAs; no change in postprandial BAs	[28]
Morbidly obese, n = 6, preoperative BMI = 44	Gastric banding	42 d	Not presented	No change	[138]
Morbidly obese, n = 28, BMI = 46.0	Gastric banding	6-28 mo	Decreased serum glucose	Decreased primary BAs	[145]
			Decreased serum insulin	No change in deoxycholic BAs
Morbidly obese, n = 7, BMI = 43	LSG	1 wk, 3 mo, 1 yr	Decreased HOMA-IR	Decreased BAs after 1 wk	[147]
				Increased BAs after 3 mo and 1 yr
Morbidly obese, n =18, BMI = 60	LSG	6 mo	Decreased: fasting glucose , fasting insulin, HOMA-IR and HBA1c	No change in total BAs	[148]
				Decreased primary BAs
				Increased secondary BAs
Obese females, n = 17, BMI = 43	LSG	24 mo	Decreased: HbA1c, insulin,	Increased total BAs	[29]
			HOMA-IR.
Morbidly obese, n =15, BMI = 45	LSG and LAGB	1 and 3 mo	Decreased: HbA1c, insulin and HOMA-IR	Increased total, primary and secondary BAs	[146]
Morbidly obese, n = 8	RYGB	Various (after losing 20% of body weight)	Not presented	Increased fasting and postprandial total and conjugated BAs	[28]
Morbidly obese, n = 9, preoperative BMI = 50	RYGB	2-4 yr	Lower fasting glucose and insulin	Higher total BA concentration	[103]
Morbidly obese, n = 37, nondiabetic, preoperative BMI = 48	RYGB	About 200 d	No change in fasting serum glucose	No change in BAs after surgery	[150]
Morbidly obese, n =75, diabetic, preoperative BMI = 48	RYGB	About 6 mo	Decreased fasting serum glucose and HbA1c	Increased total BAs	[150]
Severely obese women with T2DM, n = 13, preoperative BMI = 44	RYGB	1 mo and 2 yr	Decreased HOMA-IR	Reduced BAs after 1 mo	[32]
				Increased BAs after 2 yr
Obese patients, n = 63, BMI = 44	RYGB	15 mo	Decreased fasting glucose and HOMA-IR	Increased total BAs	[23]
Surgically obese, n = 5, BMI > 35	RYGB	1, 4, and 40 wk	Not presented	Increased conjugated BAs	[152]
				No changed unconjugated BAs
Obese females, n = 11, BMI = 44	RYGB	34 ± 16 mo	Increased postprandial insulin compared to controls	increased postprandial BAs comparing to controls	[149]
Morbidly obese, n = 30, BMI = 48	RYGB	8-13 mo	Decreased serum glucose and insulin concentration	Increased primary BAs, glycine BA, deoxycholic BA	[145]
Morbidly obese, n = 35, BMI = 48	RYGB	3 mo	Decreased HOMA-IR	Increased total BAs	[151]
Obese patients, n = 30, BMI = 46	RYGB	12 mo	Decreased fasting glucose and HOMA-IR	Increased total BAs, decreased taurine conjugated BAs	[153]
Morbidly obese, n = 7, BMI = 50	LRYGB	1 wk, 3 mo, 1 yr	Decreased HOMA-IR	Decreased BAs after 1 wk	[147]
				Increased BAs after 3 mo and 1 yr
Morbidly obese, n = 19, BMI = 43	LRYGB and LSG/DJB	1 and 3 mo	Decreased HBA1c, insulin, and HOMA-IR	Increased total, primary and secondary BA concentration	[146]
Morbidly obese, n = 12, preoperative BMI = 49	Gastric bypass	42 d	Not presented	Increased total BAs	[138]

LSG: Laparoscopic sleeve gastrectomy; LAGB: Laparoscopic adjustable gastric banding; LSG/DJB: LSG with duodeno-jejunal bypass; RYGB: Roux-en-Y gastric bypass; LRYGB: laparoscopic RYGB.